Oral infections can potentially lead to systemic diseases, making their prevention a key priority. One of the most common conditions among complete denture users is denture stomatitis. Developing removable dentures from materials with antimicrobial properties offers a potential solution for preventing this issue. This review examines different modified denture materials, focusing on their antimicrobial effects, advantages, and limitations. It also addresses unresolved aspects regarding their clinical application. A comprehensive search was conducted across 4 databases: Web of Science, PubMed, Google Scholar, and Scopus. The findings show that the incorporation of different modifying agents has led to the development of numerous denture materials with proven antimicrobial properties. These materials, which effectively reduce the growth of pathogens associated with denture stomatitis, can be integrated into modern preventive strategies. However, further clinical studies are needed to evaluate their antimicrobial efficacy in real-world oral conditions, considering the influence of systemic and local factors.
