Multiple Sclerosis (MS) is an inflammatory disease that destroys neurons, which, in addition to physical and mental complications, has devastating effects on oral health. Despite many investigations in the field of oral health in people with MS, no study has been conducted to investigate the life quality related to oral health in these people. This study aimed to investigate the life quality related to oral health in people with MS. In this case-control research, there were 103 people with MS and 103 healthy individuals. People of both groups completed the standardized OHIP (Oral Health Impact Profile) questionnaires and the evaluation of indicators associated with oral health behavior. Caries index was also recorded and measured for both groups. Finally, the data were analyzed in SPSS23 software using T-test and Mann-Whitney tests and linear regression between variables. The life quality related to oral health in the group of people with MS was statistically significantly lower than the healthy group (P = 0.032) in terms of performance limitation. In addition, the caries index score was remarkably higher in MS patients (P = 0.025). According to the obtained results, it seems that the life quality related to oral health in patients with MS is not significantly different compared to healthy people, despite having more caries. Qualitative studies are needed to better express the problems of these patients in this field.
