This systematic review evaluated the efficacy of Ionoseal as a sealing and lining material in dental restorations by analyzing its clinical performance. The study used secondary data collection and analysis, using the PRISMA guidelines for systematic reviews and meta-analyses as the chosen methodological framework. The research process involved defining exclusion and inclusion criteria for article selection and using the Cochrane risk of bias tool for evaluating potential biases. Data presentation was enhanced through a structured tabulation of findings and criteria. A procedural PRISMA approach facilitated the screening of multiple studies, ultimately narrowing the selection to 15 peer-reviewed scholarly articles that met the pre-specified inclusion criteria. The findings showed that Ionoseal demonstrated a compressive strength of 226 MPa and a transverse strength of 95 MPa. These values were further confirmed by empirical research from different perspectives. Ionoseal proves to be a reliable lining and sealing agent due to its high compressive and transverse strengths, resistance to acidic environments, ability to prevent microbial penetration, strong bonding, and flexural properties, and suitability for esthetic dental applications.
