Little was known about the physical characteristics of the new bioceramic “Cerafill” root canal sealer when it first hit the market. This study sought to evaluate its properties in comparison to the previous iteration, “iRoot.” Fresh pastes of each sealer underwent a setting time test. The set discs were submerged in deionized water to measure the solubility percentage, pH variations, and calcium ions (Ca++) released after 1, 7, 14, and 28 days. In addition, each sealer's film thickness and flowability were evaluated. When P < 0.05, the ANOVA statistical test was applied. In comparison to iRoot, Cerafill showed a significantly lower solubility percentage and a faster start and final setting time (P < 0.001). With no discernible difference, Cerafill and iRoot both showed high alkaline media ranges (9.17–11.52) and released Ca++ (P < 0.01). iRoot showed the highest flow and the lowest film thickness (22.2 ± 0.12 mm and 50 ± 0.2 µm, respectively) in comparison to Cerafill (19.5 ± 0.5 mm and 70 ± 20 µm, respectively). Setting periods, solubility, pH variations, Ca++ release, flowability, and film thickness are all improved in the new Cerafill, which satisfies the specifications for the perfect root canal sealer.
