Previous studies have identified oral microorganisms within biopsy samples from individuals with Age-Related Macular Degeneration (ARMD), and bone resorption in the alveolar region has been correlated with this ocular disorder. Hence, this case–control study explored the potential link between ARMD and periodontal disease by assessing both clinical and radiographic periodontal characteristics—primarily between patients and controls, and secondarily within ARMD cases according to their risk factors—to uncover a possible shared pathogenic mechanism. Eighty participants were recruited, comprising 40 ARMD patients and 40 controls without ARMD, matched for gender and age (±3 years) and comparable regarding ARMD-associated risk variables. Each underwent full-mouth periodontal charting, panoramic X-rays, and medical data collection, including ARMD risk information. Data were analyzed with the R statistical language, and group comparisons employed both standard t-tests and Yuen’s bootstrap-adjusted test. Participants were all aged 55 years or older, with 50 females and 30 males equally distributed across groups. No statistically significant variation emerged in clinical or radiographic periodontal indices between ARMD and control groups. Within the ARMD cohort, no significant differences were detected between periodontal indicators and ARMD risk factors, except that Clinical Attachment Level scores were notably higher in hypertensive subjects. These results suggest a potential association between periodontal pathology and ARMD among hypertensive patients, indicating hypertension might serve as a shared pathogenic pathway.
