The Purpose Of This In Vitro Research Was To Assess The Accuracy Of Intraoral Scans Acquired With The Trios 3shape® (3shape Trios, Copenhagen, Denmark) And Carestream Cs 3600™ (Carestream Dental, Stuttgart, Germany) Devices, Measured Against Conventional Polyvinyl Siloxane (Pvs) Impressions. The Reference Standard Employed Was A Laboratory Scanner. The Study Was Constructed Around 3d-Printed Master Models Reproduced From Partially Edentulous Clinical Cases Formerly Treated At Our Department (2017–2022)—All Cases Required At Least 2 Implants. Statistical Evaluation Was Conducted Using One-Way Anova And Two-Sample Z-Tests (Α = 0.05) To Assess Mean Deviations And Variability. All Techniques Achieved High Accuracy, With Deviations From The Reference Point Of Less Than 30 Μm. The Digital Intraoral Scanners (Trios 3shape® And Carestream Cs 3600®) Exhibited Superior Accuracy Compared With Pvs Analog Impressions, With No Statistically Significant Difference Between The Two Ios Devices. Within The Constraints Of This In Vitro Study, Clinically Acceptable Accuracy Was Achieved By Both Ios Systems And Pvs Analog Impressions Alike. The Digital Systems Yielded Improved Performance In Terms Of Mean Deviation And Consistency. The Greater Accuracy And Consistency Of Digital Impressions May Improve Clinical Efficiency And Prosthetic Fit In Implant Rehabilitations. From A Clinical Perspective, These In Vitro Data Suggest That Digital Impressions Could Improve Prosthetic Fit And Workflow Efficiency, Though Additional In Vivo Corroboration Is Warranted. Clinical Significance: This Investigation Supports The Reliability Of Intraoral Scanning Compared With Conventional Impressions In Implant-Supported Rehabilitations. By Evidencing Strong Intrinsic Accuracy, These Results Contribute To Streamlining Digital Workflows In Implant Dentistry And Bolster The Promise Of Intraoral Scanning Within Static Computer-Guided, Flapless Implant Surgery. Neither Ethical Approval Nor Trial Registration Was Required For The Current In Vitro Inquiry, As No Patients Were Directly Involved During The Experimental Stage. The Digital Data Used To Fabricate The Laboratory Master Models Were Derived From A Separate Clinical Study Conducted At Asst Santi Paolo E Carlo, Milan (Ethics Committee Approval No. 1361, 12 July 2017; Clinicaltrials.Gov Registration, Unique Protocol Id 1361).
