Hypermobile joint syndrome (HJS) predisposes individuals to musculoskeletal issues, with temporomandibular disorders (TMDs) and cervical spine problems representing significant contributors to disability and functional impairment. This study investigated the occurrence of TMD symptoms and assessed both TMJ and neck-related disability among young adults with HJS. A two-phase survey was carried out on physical therapy students, averaging 21 years of age. Initially, participants were screened for HJS using the Beighton scale and Brighton criteria, resulting in 56 individuals classified as HJS and 60 HJS-free controls. In the second phase, all participants completed a self-reported questionnaire addressing TMD symptoms. Disability was measured via the TMD disability questionnaire (TMD-Q) and the neck disability index (NDI), while pain intensity was quantified using a numeric rating scale (NRS). Compared with controls, the HJS group reported markedly higher pain levels across headache, TMJ, and neck/shoulder regions (p < 0.001), along with elevated TMD-Q and NDI scores (p < 0.001). Strong positive associations were found between TMD-Q and NDI scores (p = 0.0035), TMD-Q and TMJ symptom scores (p = 0.0047), and between NDI and TMJ symptom scores in both HJS and control groups (p < 0.001). Young adults with HJS exhibit greater TMJ and cervical spine disability and heightened musculoskeletal pain. These findings highlight the need for careful TMJ evaluation prior to dental or prosthetic procedures and suggest incorporating TMJ and neck disability assessments into routine care for HJS patients, ideally within a multidisciplinary treatment framework.
