This systematic review investigates how high-frequency vibrations (>30 Hz) and low-frequency vibrations (≤30 Hz) influence orthodontic tooth movement (OTM). Articles were collected through a systematic search in MEDLINE and SCOPUS, following PRISMA guidelines and structured around a PICO question. Data from selected studies were extracted, and study quality was evaluated using EPHPP, ROBINS-I, and STAIR assessment tools. From an initial pool of 350 studies, 30 met the inclusion criteria. Overall, low-frequency vibrations did not demonstrate consistent acceleration of OTM in either aligner-based or fixed orthodontic treatments, though isolated studies reported slight improvements. In contrast, high-frequency vibrations were associated with enhanced aligner exchange rates, tooth displacement, and space closure during fixed appliance therapy. In vivo research particularly indicated that vibrations between 60 Hz and 120 Hz stimulate bone biomarkers, promoting alveolar bone remodeling. The evidence suggests that high-frequency mechanical stimulation can effectively accelerate OTM, showing positive outcomes across both experimental and clinical settings. However, broader and more standardized studies are needed to confirm its therapeutic potential in orthodontics.
