TY  - JOUR
T1  - The Role of Plant Extracts in the Perspective of Oral Squamous Cell Carcinoma Treatment
A1  - Kamila Alibekovna Saypulaeva
A1  - Saniyat Zubairugadjievna Alieva
A1  - Gindi Garunovna Gazieva
A1  - Albina Ruslanovna Israfilova
A1  - Asiyat Shakhbanovna Gusenova
A1  - Aminat Ruslanovna Musieva
A1  - Arevik Simenovna Anesyan
A1  - Elizaveta Evgenyevna Kiseleva
A1  - Tamara Igorevna Tsibirova
A1  - Sabina Alievna Uzhbanokova
JF  - Asian Journal of Periodontics and Orthodontics
JO  - Asian J Periodontics Orthod
SN  - 3062-3499
Y1  - 2026
VL  - 6
IS  - 1
DO  - 10.51847/5jXDuCL5i1
SP  - 59
EP  - 71
N2  - Oral squamous cell carcinoma remains a pressing issue due to high incidence, late diagnosis, and limited effectiveness of standard treatments with severe toxic effects. This study compared the antitumor activity and safety of Curcuma longa, Camellia sinensis, and Nigella sativa extracts in a rat model of DMBA-induced oral cancer. The experiment involved 78 adult male Wistar rats. Acute toxicity was assessed at 5000 mg/kg. Tumors were induced by applying 0.5% DMBA to the buccal mucosa three times weekly for 16 weeks. Animals received saline, plant extracts (500 mg/kg each), or cisplatin (2 mg/kg) for 8 weeks. Tumor measurements were performed weekly. Histological, immunohistochemical (Ki-67, caspase-3), and biochemical analyses were conducted. All extracts showed antitumor activity without toxicity. Black cumin extract demonstrated the highest efficacy, reducing tumor incidence to 70% (vs. 100% in controls) and decreasing tumor volume 2.8-fold (650 vs. 1850 mm³), achieving 64.9% growth inhibition. Immunohistochemistry revealed decreased Ki-67 to 31.4% (vs. 68.3%) and increased caspase-3 to 34.2% (vs. 8.2%), approaching cisplatin values (28.7% and 38.5%). Turmeric and green tea extracts showed moderate effects with 80% incidence and 47.0-52.4% inhibition. Cisplatin caused significant hepato- and nephrotoxicity, while plant extracts maintained normal parameters. All extracts suppress proliferation and induce apoptosis. Black cumin extract showed cisplatin-comparable efficacy without toxicity, supporting its further investigation for oral cancer management.
UR  - https://tsdp.net/article/the-role-of-plant-extracts-in-the-perspective-of-oral-squamous-cell-carcinoma-treatment-egh3xcbqiijopkv
ER  -