TY - JOUR T1 - Regenerative Periodontal Therapy for Vital Teeth with Extensive Attachment Loss at the Root Apex: Two Cases with 5-Year Follow-Up A1 - Pei Chen Lin A1 - Tomoko Mukai JF - Asian Journal of Periodontics and Orthodontics JO - Asian J Periodontics Orthod SN - 3062-3499 Y1 - 2024 VL - 4 IS - 1 DO - 10.51847/fWQQVl1I8j SP - 88 EP - 97 N2 - Teeth exhibiting attachment loss that extends to the root apex are considered to have a severely compromised condition and an unfavorable periodontal outlook. When regeneration of periodontal structures is achievable, current protocols recommend performing endodontic therapy first. Nonetheless, root canal procedures may prolong treatment duration, elevate costs, introduce endodontic complications, and potentially weaken tooth structure mechanically. In this report, two individuals diagnosed with periodontitis stage III/IV grade C—without a smoking or diabetic history—presenting with apical attachment loss, were successfully managed through guided tissue regeneration. These two cases stand out as periodontal regeneration was achieved without prior endodontic therapy, and tooth vitality was preserved over time. The report outlines the management strategy that produced this clinical success and defines key factors for proper case selection. Within the scope of this study, vital teeth exhibiting radiographic bone loss involving the apex can be effectively treated with periodontal regenerative therapy and remain vital at least in the short to mid-term. UR - https://tsdp.net/article/regenerative-periodontal-therapy-for-vital-teeth-with-extensive-attachment-loss-at-the-root-apex-tw-j6qxfig9ymuddet ER -