This systematic review aimed to evaluate existing evidence on the use of enamel matrix derivatives (EMDs) as an adjunctive therapy in alveolar ridge preservation (ARP) following tooth extraction. An extensive search was performed across MEDLINE, the Cochrane Library, PsycINFO, Web of Science, Google Scholar, and Scopus to locate randomized controlled clinical trials (RCTs) relevant to this topic. The main outcomes assessed included histomorphometric and radiographic parameters, while secondary outcomes involved implant placement feasibility and patient-centered factors such as postoperative discomfort. From 436 studies published between 2011 and 2022, only five met the inclusion criteria, encompassing a total of 146 patients. Owing to considerable variability across studies, a meta-analysis was not feasible. Qualitative assessment revealed slight improvements, including a higher proportion of new bone formation and reduced postoperative discomfort following extraction. Although EMDs have demonstrated regenerative benefits in other dental applications, their adjunctive use in ARP warrants further exploration. Additional well-designed randomized clinical trials are essential to clarify their precise efficacy and clinical relevance.
