TY  - JOUR
T1  - "Molecular Characterization of Granular Cell Tumors and Oral Cavity Schwannomas"
A1  - Ana Souza
A1  - Pedro Lima
A1  - Juliana Costa
JF  - Journal of Dental and Allied Oral Health Sciences
Y1  - 2022
VL  - 2
IS  - 1
SP  - 20
EP  - 33
N2  - Granular cell tumours (GCTs) are infrequent submucosal growths, presumed to arise from Schwann cells, distinguished by large polygonal cells containing numerous lysosomes. This study sought to explore whether GCTs display features of antigen-presenting cells (APCs) or neural crest cells (NCCs) using immunohistochemistry and to contrast their expression patterns with Schwannomas. Expression of APC-associated markers (CD68, HLA-DR, CD163, CD40, CD11c) and NCC-associated markers (S100, SOX10, NSE, GAP43) was analyzed in 23 GCTs and 10 Schwannomas. Furthermore, RT-qPCR was conducted on 6 GCT cases to assess a possible NCC developmental signature. GAP43 emerged as a novel NCC marker for GCTs, while CD68 and HLA-DR staining provided limited support for an APC-like profile. RT-qPCR did not detect an NCC developmental program in GCTs, likely due to technical constraints.
UR  - https://tsdp.net/article/kJ3EwbAaFlBz6wBZxbhv
ER  -