Endocrowns have become widely accepted as an alternative to conventional fixed partial dentures and post-core restorations. From a mechanical standpoint, traditional endodontically treated cavities exhibit low fracture resistance. In contrast, ceramic endocrowns typically feature an occlusal portion ranging in thickness from 3 to 7 millimeters. Research suggests that increasing this occlusal thickness enhances the fracture resistance of ceramic endocrowns. This systematic review aimed to investigate the relationship between mechanical properties, occlusal fit, and the success rates of CAD/CAM-designed ceramic endocrowns. To ensure the reliability of the findings, the study followed systematic review protocols and adhered to PRISMA meta-analysis guidelines in selecting relevant literature. The principal investigator outlined the research methodology by specifying the inclusion and exclusion criteria. In addition, a Cochrane risk of bias assessment was performed and presented in a tabular format. After a rigorous screening process, 13 peer-reviewed studies met the inclusion criteria. A structured summary of the objectives and findings of each study facilitates a clear interpretation of the results. The discussion critically analyzed these empirical findings, offering valuable insights into the topic. Finally, the review concluded that CAD/CAM-designed ceramic endocrowns are one of the most effective restorative options in modern prosthodontics.