Adipocyte stem cells (ADSCs), a type of mesenchymal stem cell sourced from adipose tissue, play a significant role in the advancement of novel therapies due to their proven efficacy in developing new treatments. These pluripotent cells have the potential to differentiate into various cell types, including adipocytes (fat cells), myocytes (muscle cells), osteocytes (bone cells), and neurons (nerve cells). To assess the role of ADSCs in the treatment of cleft lip and palate, a systematic review of literature published from 2012 to 2022 was conducted using databases such as PubMed, ScienceDirect, and Medline. The search focused on keywords such as “cleft lip treatment,”, “adipocyte stem cells,” and “cleft palate treatment.” Despite the small number of relevant studies, the findings suggest that ADSCs have shown promise in the management of cleft palate, with satisfactory outcomes in certain cases. However, the current evidence remains insufficient to support the widespread clinical application of ADSCs for routine use by oral surgeons in cleft palate reconstruction.
