%0 Journal Article
%T Evaluation of NPAS2 and Rev-Erb-α Serum Levels in Obstructive Sleep Apnea: Exploring Links Between Glucose Metabolism, Circadian Rhythm, and Hypoxia – A Pilot Study
%A Roberto Lozano
%A Marta Llorente-Alonso
%A Fabio Camacho-Alonso
%J Annals Journal of Dental and Medical Assisting
%@ 3062-3510
%D 2025
%V 5
%N 1
%R 10.51847/zaktNc8z25
%P 87-91
%X Obstructive sleep apnea (OSA) is recognized as a risk factor for type 2 diabetes mellitus (DM2). Since OSA disrupts circadian rhythms, it can influence circadian clock proteins such as neuronal PAS domain protein 2 (NPAS2) and nuclear receptor subfamily 1 group D member 1 (Rev-Erb-α). These proteins have been linked to metabolic disturbances, including insulin resistance. This pilot study aimed to examine serum levels of NPAS2 and Rev-Erb-α in patients with severe OSA and those with severe OSA combined with DM2, compared to healthy controls, and to assess their correlations with polysomnography (PSG) parameters, including oxygen saturation (SpO₂) measures. Forty participants were enrolled and divided into three groups: OSA (n = 17; AHI > 30, without DM2), OSA+DM2 (n = 7; AHI > 30 with DM2), and controls (n = 16; AHI < 5, without DM2). All participants underwent overnight PSG followed by morning blood sampling. Serum NPAS2 and Rev-Erb-α levels were quantified using enzyme-linked immunosorbent assay (ELISA). Mean NPAS2 levels were significantly lower in the OSA group compared to healthy controls (p = 0.017). The OSA group also showed lower NPAS2 levels than the OSA+DM2 group, though this difference only approached significance (p = 0.094). No significant differences were observed in Rev-Erb-α concentrations. A negative correlation was found between AHI during REM sleep and NPAS2 serum levels (r = −0.478; p = 0.002). NPAS2 serum levels may play a role in the metabolic dysregulation observed in OSA patients, potentially through mechanisms linked to REM sleep.
%U https://tsdp.net/article/evaluation-of-npas2-and-rev-erb-a-serum-levels-in-obstructive-sleep-apnea-exploring-links-between-g-nwhwrl6fo34dpwv