TY  - JOUR
T1  - Effect of Adding 8 mg Dexamethasone to 2% Lignocaine with Adrenaline in Inferior Alveolar Nerve Block for Mandibular Third Molar Surgery: A Split-Mouth Randomized Double-Blind Study
A1  - Ivan Petrov
A1  - Olga Ivanova
A1  - Dmitry Smirnov
JF  - Journal of Current Research in Oral Surgery
JO  - J Curr Res Oral Surg
SN  - 3062-3480
Y1  - 2026
VL  - 6
IS  - 1
DO  - 10.51847/G5nORWwGHZ
SP  - 90
EP  - 106
N2  - Extraction of impacted lower third molars induces trauma within a highly vascularised area characterized by loose connective tissue, triggering a cascade of inflammatory after-effects, including postoperative discomfort, edema, restricted mouth opening, and widespread oral impairment throughout the healing period. An encompassing technique to extend anesthesia and curb the unavoidable postoperative aftermath in minor oral surgical interventions remains insufficiently investigated. To determine the effectiveness of dexamethasone incorporated into local anesthetic solutions for lengthening anesthetic depth and duration while diminishing postoperative morbidity following the surgical removal of impacted third molars. A prospective, controlled, randomized, split-mouth, double-blind investigation of lower third molar surgery was conducted on 35 subjects. The experimental cohort (Group I) was administered 8 mg dexamethasone combined with 2 ml of 2% lignocaine containing epinephrine. In contrast, the reference cohort (Group II) received 2 ml of sterile water combined with 2 ml of 2% lignocaine containing epinephrine. Anesthetic onset and duration were measured; subsequently, pain, swelling, and trismus were tracked over 7 postoperative days, with statistical analysis using an independent t-test and a repeated-measures ANOVA. The experimental cohort demonstrated an earlier anesthetic onset by 69 s and a prolonged anesthetic action lasting 128.4 min (P 
UR  - https://tsdp.net/article/effect-of-adding-8-mg-dexamethasone-to-2-lignocaine-with-adrenaline-in-inferior-alveolar-nerve-bloc-vcj9wzkwgufuwrs
ER  -