This study aimed to assess the understanding of dental professionals about the new classifications in diabetes mellitus, hypertension, and periodontics. Dental practitioners employed in Saudi Arabia participated in a descriptive cross-sectional survey. 180 dental practitioners completed the structured, self-reported, closed-ended questionnaire. According to the findings, 97.3% of the dentists agreed to keep up with the latest guidelines for diabetes, hypertension, and periodontics. More than 33.9% of respondents knew about the four phases and three grades of periodontitis, as per the 2017 revision of the grouping of periodontal and peri-implant illnesses. Only 14.4% of those surveyed were aware that the essential blood sugar level for any dental procedure is 240 mg/dl. The cut-off fasting blood glucose level for emergency extraction is 180 mg/dl, as 36.1% of respondents knew. According to 15% of respondents, the cut-off level of blood sugar two hours after the previous meal is 234 mg/dl. A systolic and diastolic blood pressure of 130–139/80–89 mmHg is considered stage I hypertension in 40% of cases. If the patient's systolic and diastolic blood pressures are 180 mmHg or higher or 109 mmHg or higher, over 30.6% of respondents agreed to visit a doctor first. The majority (71.7%) of the survey participants were aware that antihypertensive medicines induce xerostomia. Most of the dental practitioners who participated in the present investigation were unaware of the new diabetes and hypertension recommendations. Therefore, dental professionals are urged to attend more seminars and lectures to stay up to date with the latest dental standards regarding diabetes and hypertension.