A fibrotic and possibly cancerous condition of the oral cavity is called oral submucous fibrosis (OSMF). The areca nut's function in the pathophysiology of OSMF and its prevalence in the Southeast Asian population is well established. However, research into the risk factors and demographics of those afflicted is required to comprehend the pathogenesis of the illness. Therefore, the current retrospective study aimed to evaluate the clinicopathological characteristics of OSMF. The current analysis included OSMF cases that were clinically and histologically identified and reported between 1998 and 2018. Criteria for clinicopathological included gender, age, stage, grade, and history of habits. The chi-square test was used to examine the relationship. The male-to-female ratio of OSMF cases was 10.7:1, indicating a male predominance. A wide age range was seen from 14 to 84 years old. There was a strong correlation (P < 0.05) between the histological grade of OSMF and the clinical stage. Most of the patients (63 out of 141) had advanced OSMF grades. There was a significant association between history of habit, gender, age, and OSMF grade (P < 0.05). The current study showed that there is a strong association between tobacco and betel nut usage in the younger age group and the grade and stage of OSMF progress. The study emphasizes the necessity of educating patients about substance use and its detrimental effects on the course of their disease and their quality of life.
