External apical root resorption is characterized by the gradual blunting and shortening of the root, leading to open apices that complicate the achievement of an adequate three-dimensional seal in the root canal system. A common treatment approach for such conditions has been the placement of an apical barrier. This case report demonstrates the innovative use of an amnion membrane matrix combined with Biodentine as an apical barrier to manage apical root resorption. After performing the initial access opening, the root canals were carefully cleaned and shaped. An intracanal medication of calcium hydroxide was applied for two weeks. At the next session, an amnion membrane was placed in the apex to act as an internal matrix, and then a 5-millimeter plug of Biodentine was placed. Post-space preparation was performed, and a glass fiber post was placed with a composite core build-up. The tooth was then restored with a full-coverage porcelain fused to a metal crown. After 18 months, the patient showed no clinical signs or symptoms, with radiographs revealing the development of calcified tissue beneath the Biodentine barrier. These positive results indicate that amnion membrane matrix and Biodentine can be reliably used to manage apical root resorption.
