Osteonecrosis of the jaw (ONJ) is the most common side effect among individuals receiving immunosuppressive, anti-resorptive, antiangiogenic, and chemotherapeutic medications. Dental professionals must be knowledgeable about these drugs. Saudi Arabia has not conducted any research on this topic. This study aimed to increase awareness about MRONJ and evaluate the attitude and knowledge of dental professionals about it. This cross-sectional descriptive observation was conducted targeting fifth and sixth-year dental students and interns who were randomly selected during the oral surgery session at KAUDH. 219 students and interns made up the entire sample group, with 70 participants at each level. There are a total of 16 items and only one researcher used the questionnaire. Of the participants, 72.1% knew which dental operations could increase the risk of developing MRONJ, and 40.6% knew about the other factors that could increase MRONJ. Only 36.5% of the subjects were able to identify all drugs besides bisphosphonates, which made up 49.3% of the sample overall, and 32.4% of the participants had a favorable reaction when managing MRONJ. There were statistically significant differences between the three groups in terms of staging, severity, clinical, radiological, and preoperative referral results. 79.5% of the interviewees wanted more knowledge, and many were ignorant of the management and prevention of MRONJ. We recommend that to improve patient care, efficient measures are required to increase, strengthen, and incorporate the information.
